Configuring radioligand receptor binding assays for HTS using scintillation proximity assay technology.
نویسندگان
چکیده
منابع مشابه
Scintillation Proximity Assay (SPA): Custom Assay Development and Membrane Validation
G protein-coupled receptors (GPCRs) represent attractive drug targets because they participate in a wide range of physiological processes and are believed to play a role in a variety of disease states. At least a third of all prescription drugs on the market today are molecules acting as agonists or antagonists of the GPCR. Receptor-ligand interaction studies are pivotal in the successful ident...
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To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...
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عنوان ژورنال:
- Methods in molecular biology
دوره 190 شماره
صفحات -
تاریخ انتشار 2002